Barefoot running, also called "natural running", is the act of running without footwear. With the advent of modern footwear, running barefoot has become less common in most parts of the world but is still practiced in parts of Africa and Latin America. In some Western countries, barefoot running has grown in popularity due to perceived health benefits.

Scientific research into the practice of running barefoot has not reached a clear consensus regarding its risks or its benefits. While footwear might provide protection from cuts, bruises, impact and weather, proponents argue that running barefoot reduces the risk of chronic injuries (notably repetitive stress injuries) caused by heel striking in padded running shoes.

The barefoot movement has prompted some manufacturers to introduce thin-soled and flexible shoes such as traditional moccasins and huaraches for minimalist running.